Biology Reference
In-Depth Information
Table 1.
Human Herpesviruses and their Associated Diseases
Genome
Preferred
Associated
Virus
Subfamily
Length (kb)
Host Cells
Diseases
HHV-1
α
152
Neuroectodermal
Cold sores
(HSV-1)
HHV-2
α
152
Neuroectodermal
Genital herpes
(HSV-2)
HHV-3
α
125
Neuroectodermal
Chicken pox;
(VZV)
shingles
HHV-4
γ
172
Lymphohematopoietic;
Infectious
(EBV)
ectodermal
mononucleosis;
Burkitt's
lymphoma;
nasopharyngeal
carcinoma
HHV-5
β
230
Mesodermal, incl.
Infectious
(HCMV)
lymphohematopoietic
mononucleosis;
sialoadenitis
HHV-6
β
160
Lymphohematopoietic
Exanthem
subitum;
infectious
mononucleosis;
Kikuchi's
lymphadenitis;
infantile
febrile seizures
HHV-7
β
145
Lymphohematopoietic
Nonspecific
lymphadenitis
HHV-8
γ
165
Lymphocytic;
Kaposi's sarcoma;
(KSHV)
fibrohistiocytic, incl.
serosa-
endothelial cells
associated
lymphoma
1
Additional diseases will occur in immunodeficient patients. HHV, human herpesvirus;
HSV, herpes simplex virus; VZV, Varicella-Zoster virus; EBV, Epstein-Barr virus;
HCMV, human cytomegalovirus; KSHV, Kaposi's sarcoma-associated herpesvirus.
and Varicella-Zoster virus (VZV or HHV-3), which cause cold sores,
genital herpes and chickenpox, respectively. The betaherpesviruses
have a more restricted host range, longer reproductive cycle and
slower growth in culture. The virus can remain latent in secretory
