Insights into the Caliciviridae Family - Structure-Based Study of Viral Replication - page 387

50 225 279 406 520

N S P1-1 P2 P1-2

Fig. 4. The VP1 domains and the ribbon structure of Norwalk virus
(accession number M87661) developed using the Swiss model software
(www.expasy.org/swissmod/SWISS-MODEL.html).

described as saddle-shaped; and for SMSV4, the P2 subdomain was
described as parallelogram-shaped with a dent at the center. 29

VP1: N Terminus

The N-terminus comprises of the first 50 residues of the capsid pro-
tein (Fig. 4). This is located in the interior of the particles. The N ter-
minus of NoV VP1 is acidic and is not thought to interact directly
with the viral genome. 6 Several studies have found that deletion of the
small part of the N terminus of NoV, SaV, or RHDV did not affect