Biology Reference
In-Depth Information
Fig. 1.
Schematics of the family
Caliciviridae
. For
Norovirus
and
vesivirus
,
ORF1 encodes the non-structural proteins, ORF2 encodes the major capsid
protein (VP1), and ORF3 encodes a small protein (VP2). For
sapovirus
and
lagovirus
, ORF1 encodes the non-structural proteins and VP1, whereas
ORF2 encodes proteins of yet-unknown functions, and ORF3 (an unknown
protein) is only predicted for SaV GI, GIV, and GV genomes.
Genome
The calicivirus genome consists of a positive-sense, single-stranded
RNA of approximately 7.4 to 8.3 kb in length that is organized in
either two or three open reading frames (ORFs) (Fig. 1). NoV and
FCV have a similar genomic organization in that ORF1 encodes
non-structural proteins, including N-terminal protein, NTPase,
3A-like protein, genome-linked viral protein (VPg), 3C-like protease,
and RNA-dependent RNA polymerase (RdRp). The NoV and FCV
ORF2 encodes the major capsid protein (VP1) and the NoV and FCV
ORF3 encodes a small protein (VP2). The NoV VP2 is associated
