Biology Reference
In-Depth Information
Fig. 3.
Neutralizing epitopes in context to trimers. (Figure is adapated from
Burton
et al
. (2004)
Nature Immunol
5
: 233-236.)
act as a bridge between Fc receptor (FcR)-bearing cells and HIV-1-
infected cells or other cells that have passively absorbed HIV-1 Env
onto their surface. The killing of virus-infected cells by ADCC
involves cytotoxic cells (such as NK cells) and may contribute toward
the elimination of the virus.
23-26
Alsmadi and Tilley
27
studied the abil-
ity of human and chimpanzee mAbs directed against cluster II over-
lapping epitopes of gp41, CD4 binding site, V3 loop, and C5 domain
of gp120 for their ability to induce ADCC. They demonstrated that
mAbs directed against conserved epitopes generally exhibited ADCC
activity against a broader range of HIV-1 strains than those directed
against variable epitopes. Furthermore, it appears that many if not
most neutralizing antibodies of high affinity and of the immuno-
globulin G1 subclass (IgG1) are capable of exerting ADCC. In a
