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budding processes. Since diverse viruses seem to exploit common cel-
lular pathways and machinery, knowledge of filovirus assembly and
budding may aid in the identification and characterization of other
commonly used pathways and stimulate research in other areas. Even
more importantly, knowledge of specific interactions among filoviral
proteins may prove invaluable in identifying targets for antivirals to
Ebola and Marburg viruses.
Acknowledgments
We thank the members of our laboratory who contributed to the orig-
inal work presented in this review, Yuko Kawaoka for an illustration,
Gabriel Neumann for critical reading of the manuscript, and Susan
Watson for editing the manuscript. This work was supported by Core
Research for Evolutional Science and Technology (CREST) grants
from the Japan Science and Technology Corporation (JST), Japan.
References
1. Sanchez A, Khan AS, Zaki SR,
et al
. (2001) Filoviridae: Marburg and
Ebola viruses. In DM Knipe & PM Howley (eds),
Fields Virology
, 4th ed,
pp. 1279-1304. Lippincott/The Williams & Wilkins Co., Philadelphia, Pa.
2. Geisbert TW, Jahrling PB. (1995) Differentiation of filoviruses by elec-
tron microscopy.
Virus Res
39
: 129-150.
3. Schmitt AP, Lamb RA. (2004) Escaping from the cell: assembly and
budding of negative-strand RNA viruses.
Curr Top Microbiol Immunol
283
: 145-196.
4. Feldmann H, Klenk HD. (1996) Marburg and Ebola viruses. In
Maramorosh K, Murphy FA, Shatkin AJ (eds),
Advances in virus research
,
vol. 47, pp. 1-52. Academia Press, Inc.
5. Garoff H, Hewson R, Opstelten DJ. (1998) Virus maturation by bud-
ding.
Microbiol. Mol Biol Rev
62
: 1171-1190.
6. Jasenosky LD, Neumann G, Lukashevich I, Kawaoka Y. (2001) Ebola virus
VP40-induced particle formation and association with the lipid bilayer.
J Virol
75
: 5205-5214.
7. Ruigrok RW, Schoehn G, Dessen A,
et al
. (2000) Structural characteri-
zation and membrane binding properties of the matrix protein VP40 of
Ebola virus.
J Mol Biol
300
: 103-112.
