Biology Reference
In-Depth Information
Category A
Category B
Bacillus anthracis (anthrax)
(2)
Burkholderia pseudomallei
(2)
•
•
Clostridium botulinum
(2)
Coxiella burnetii (Q fever)
(1)
•
•
Yersinia pestis
(8)
Brucella species (brucellosis)
(1)
•
•
Burkholderia mallei (glanders)
(2)
•
Variola major (smallpox) & other pox
viruses
(6)
•
Ricin toxin (from Ricinus communis)
(7)
•
Francisella tularensis (tularemia)
(7)
•
•
Epsilon toxin of Clostridium perfringens
(2)
Viral hemorrhagic fevers
(6)
o
Arenaviruses
LCM, Junin virus,
Machupo virus,
Guanarito virus
Lassa Fever
o
Bun
y
aviruses
Hantaviruses
Rift Valley Fever
o
Flaviruses
Dengue
o
Filoviruses
Ebola
Marburg
•
Staphylococcus enterotoxin B
(5)
•
Typhus fever (Rickettsia prowazekii)
(1)
•
•
Food and Waterborne Pathogens
o
Bact
e
ria
Diarrheagenic E.coli
(8)
Pathogenic Vibrios
(5)
Shigella species
(8)
Salmonella
(8)
Listeria monocytogenes
(5)
Campylobacter jejuni
(5)
Yersinia enterocolitica
(8)
o
Viruses (Caliciviruses, Hepatitis
A)
(1)
o
Protozoa
Cryptosporidium
parvum
(3)
Cyclospora
cayatanensis
Giardia lamblia
(7)
Entamoeba histolytica
(2)
Toxoplasma
(3)
Microsporidia
(7)
Category C Emerging infectious disease threats
such as Nipah virus
(6)
and additional
hantaviruses.
NIAID priority areas:
Tickborne hemorrhagic fever viruses
(6)
o
Crimean-Congo Hemorrhagic
fever virus
•
Tickborne encephalitis viruses
(6)
•
•
Additional viral encephalitides
o
West Nile Virus
(6)
o
LaCrosse
o
California encephalitis
(6)
o
VEE
(6)
o
EEE
(6)
o
WEE
(6)
o
Japanese Encephalitis Virus
(6)
o
Kyasanur Forest Virus
(6)
Yellow fever
(6)
•
Multi-drug resistant TB
(7)
•
Influenza
(7)
•
Other Rickettsias
(1)
•
Rabies
(1)
•
•
Severe acute respiratory syndrome-
associated coronavirus (SARS-CoV)
(1)
(Note: SARS-CoV added August 30, 2004
)
Fig. 1.
The list of pathogens in the Categories A, B and C as assigned by
NIAID. (Source: http://www2.niaid.nih.gov/biodefense/bandc_priority.htm).
The number following the pathogen name indicates the corresponding BRC
assigned as in Table 1.
cells to their environment. At PATRIC, we define the pathogen-host-
environment triangle as a PathoSystem. Different factors at each of
these nodes converge to influence the outcome of an infection, which
may range from microbe-clearance to full-blown disease. It will be our
