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Fig. 5. Overview of the structure of the AMV coat protein-RNA complex
(A) and detailed interactions of the interhelical (B) and 3ยด-terminal AUGC
repeats (C) (1XOK).
The amino acids found in the conserved RNA binding motif of
AMV coat protein stabilize the AUGC base pairing interactions via
hydrogen bonds and stacking interactions. The crucial arginine residue
(Arg 17) is located at a central position within the structure and inserts
into the base stack at the major groove. Its position allows it to form
hydrogen bonds with the bases of G867 (G17 of peptide 1) and G880
(G17 of peptide 2). Tyrosine 21 stacks below the A:U pair at the base
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