Biomedical Engineering Reference
In-Depth Information
to treat any further. Heating prior to the enzymatic digestion step is used to denature and
solubilize the DNA. Following this pretreatment, several enzymes (alcalase, phospho-
lipidase, lecitase, and lysozymes) are used to solubilize the non-PHB cell components.
The PHB from such an isolation procedure contain at least some cell debris. The purity
can be achieved by an extra purification step by solvent extraction.
aPPliCatioN oF PhB
Packaging
For preparation of films, blow molded bottles and paper, disposal items such as razors,
utensils, diapers and feminine, PHB are used.
medical Field
Its slow and
in vivo
degradability proves it a potential candidate for use in reconstruc-
tive surgery. Development of cardiovascular products such as pericardial patches, vas-
cular grafts, heart valve. It can also be used for controlled drug release system. The
4 HB units are pharmacologically active compounds, therefore are very suitable for
treatment of alcohol withdrawal syndrome, narcolesy, chronic schizophrenia, cataton-
ic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, drug addiction
and withdrawal, Parkinsons's disease, circulatory collapse, radiation exposure, cancer,
myocardial infarction, and other neuropharmacological illnesses.
disposable Personal hygiene
PHB can be used as sole structural materials or as parts of degradability plastics.
tissue engineering scaffolds
The suitable material properties of PHB such as compatibility, support cell growth,
guide and organize cells allow tissue in growth.
agricultural
The PHB are biodegraded in soil. Therefore, the use of PHB in agriculture is very
promising. They can be used as biodegradable carrier for long-term dosage of insec-
ticides, herbicides, or fertilizers, seedling containers and plastic sheaths protecting
saplings, biodegradable matrix for drug release in veterinary medicine, and tubing for
crop irrigation. Here again, it is not necessary to remove biodegradable items at the
end of the harvesting season.
KeyWords
•
Bioplastic
•
lysozymes
•
Petrochemical polyesters
•
Polyhydroxyalkanoate
•
Pyruvate molecules
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