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encoding the finite-state transition rule. Then a restriction enzyme, which
recognized the sequence encoding the current input as well as the current state,
cut the appended end of the linear DNA nanostructure to expose a new a sticky-
end encoding the next state. The hardware-software complex is composed
of dsDNA with an ssDNA overhang (shown at top left ready to bind with the
input molecule) and a protein restriction enzyme (shown as gray pinchers). See
Figure 13.7 for further details. This ingenious design is an excellent demonstration
that there is often more than one way to do any task at the molecular scale.
Hardware
−
software
complex
S0,b
Input molecule
b
S0
S1
S1,
σ
Remaining input
a
S1
S0
S0,b
b
S0
S1
S0,t
Output = S0
Figure
13.7.
Autonomous finite-state computations via disassembly of DNA
nanostructures. (Figure adapted with permission from [13]).
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