Biomedical Engineering Reference
In-Depth Information
for the specific application and hence are not easily transferable to other appli-
cations. We think that biosensors based on molecular switches offer a promising
tool to solve this problem, because in this case it is only the analyte binding which
is able to generate a signal response (provided that cross-reactivity is excluded).
Molecular switches have been reported for optical and electrochemical transduc-
tion principles, which are currently the most commonly used transduction prin-
ciples for biosensors.
A powerful biosensor system requires a high-performance biosensor component
as well as a user-friendly instrumental setup. However, biosensor setups have to be
adapted to specific applications. As disease-related marker profiles are still under
investigation, specifications regarding a suitable biosensor instrument can hardly
be given at the moment. But, almost certainly, such a device should permit
multiplex analysis to determine a marker profile in a sample in one measurement
cycle. Therefore, a biosensor array would be required. At least as long as these
profiles are not established, it could be useful to keep these arrays flexible. This
would be supported by a packaging strategy in which each biosensor element is
integrated in a single, array-compatible housing allowing user-defined combina-
tion. This would make the arrays potentially adaptable to the respective application
and hence make the underlying biosensor instrument more versatile.
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