Biomedical Engineering Reference
In-Depth Information
Integration in Bioanalysis: Technologies
for Point-of-Care Testing
Frank F. Bier and Soeren Schumacher
Abstract Biosensors, Lab-on-Chip technologies, and sensor-actor molecules are
steps towards the integration of bioanalysis into small devices that will help in
providing analysis where it is needed: the point-of-care. This article gives a brief
overview of recent achievements and future prospects.
Contents
1
Introduction..........................................................................................................................
2
1.1
The Concept of Molecular Biomarkers .....................................................................
2
1.2
Societal Needs ............................................................................................................
3
1.3
Integration as a Key Parameter..................................................................................
4
2
Integration Steps ..................................................................................................................
5
2.1
Biosensors and Biochips.............................................................................................
6
2.2
Lab-on-Chip Systems .................................................................................................
9
2.3
Integration on the Chip: ''Active Arrays''.................................................................
10
2.4
Autonomous Biosensors .............................................................................................
11
2.5
Sensor-Actor Molecules: Molecular Integration .......................................................
12
3
The Goal: Systems Integration ...........................................................................................
12
References..................................................................................................................................
13
F. F. Bier (
)
S. Schumacher
Fraunhofer Institute for Biomedical Engineering (IBMT),
Branch Potsdam, Am Mühlenberg 13, 14476 Potsdam, Germany
e-mail: frank.bier@ibmt.fraunhofer.de
URL: www.ibmt.fraunhofer.de; www.taschentuchlabor.de;
www.theradiagnostik.de; www.ivd-plattform.de
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