Biomedical Engineering Reference
In-Depth Information
Bone diseases, are in close relationship with population aging process and therefore their
treatments are a great challenge for the scientific community. The development of bone tar-
geted bioactive DDS using a bone substitute provides an attractive and efficient approach for
the treatment of bone pathologies not only from clinical and scientific viewpoints but also at a
social and economical level. Of course, the therapeutic window for CaP ceramic DDS is mainly
based on in vitro results and animal studies do not always extend well to human situations, but
this could be a good starting point for clinical trials. In addition, the approval of sustained
release systems, such as those described here, may make possible the development of important
innovative therapeutic-based strategies (vaccines or gene transfer) for the management of chronic
bone affections in the near future.
Acknowledgments
The individual and collaborative studies involving the authors were supported by research
grants from the INSERM CJF 93-05 and CNRS EP 59 [Dr. G. Daculsi, Director] and from
the National Institute for Dental Research of the National Institutes of Health Nos. DE04123
and DE07223 and special Calcium Phosphate Research Funds [Dr. R.Z. LeGeros, Principal
Investigator].
The authors wish to thank P. Pilet from the regional center of electron microscopy (Nantes
University Hospital) for help full discussions.
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