Biomedical Engineering Reference
In-Depth Information
engraftment in many patients. Development of strategies to expand functional
transplantable hepatocytes will significantly increase the success of liver regen-
eration. We have shown that durable hepatic reconstitution requires cellular
interaction between hepatocytes and the liver vascular niche demarcated by spe-
cialized liver SECs [
65
]. Production of liver SECs-derived paracrine growth fac-
tors, which we define as ''angiocrine factors'', has been shown to initiate and
maintain hepatocyte regeneration, underscoring the urgency to develop cell ther-
apy approaches to rebuild not only hepatic but also vascular function for liver
diseases.
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