Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration - Mechanical and Chemical Signaling in Angiogenesis - page 34

Fig. 6 a Kinetics of liver SEC expansion and b hepatocyte mitosis during liver regeneration
(n = 4). c Proposed schema describing the roles of SECs in liver regeneration. Upon partial
hepatectomy (day 0), LSECs initiate the proliferation of proximal hepatocytes by exerting
''inductive signals'', possibly by releasing angiocrine factors. Day 4 post-PH, there is a significant
liver SEC expansion (proliferative angiogenesis) to sustain hepatic reconstitution. Scale bars,
50 lm. Error bars, SEM
Fig. 7 Partial hepatectomy induced VEGFR2-Id1 activation in LSECs mediates liver regener-
ation. a, b Hepatocyte proliferation after partial hepatectomy is impaired in VEGFR2 fl/fl mice
(n = 5). c-e Inhibition of liver mass regeneration c and functional VE-cadherin + isolectin + vessel
formation d, e in VEGFR2 fl/fl mice after partial hepatectomy (n = 4-6). **P \ 0.001. Scale bar,
50 lm. Error bars, SEM (Adapted from [ 65 ])