Biomaterials for Cell-Based Therapeutic Angiogenesis - Mechanical and Chemical Signaling in Angiogenesis - page 242

Biomaterials for Cell-Based Therapeutic
Angiogenesis
Max H. Rich and Hyunjoon Kong
Abstract Stem cells and endothelial progenitor cells are increasingly studied for
use in therapeutic angiogenesis to treat ischemic tissues and critical-sized tissue
defects because of their potential to sustainably express multiple angiogenic fac-
tors and also differentiate to endothelial cells. These cells are often incorporated
into a variety of biomaterials which can function as a provisional matrix to localize
or deploy cells and also to regulate cellular phenotypic activities at a transplan-
tation site. This chapter will summarize previous and current efforts to design cell-
laden biomaterials in order to improve therapeutic efficacy of transplanted cells to
stimulate revascularization. Finally, it will discuss future strategies of biomaterial
design that can further elevate the quality of the cell-based revascularization
therapy.
M. H. Rich H. Kong ( & )
Department of Chemical and Biomolecular Engineering,
University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
e-mail: [e-mail]
M. H. Rich
e-mail: [e-mail]
H. Kong
Institute for Genomic Biology, University of Illinois at Urbana-Champaign,
Urbana, IL 61801, USA
H. Kong
Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign,
Urbana, IL 61801, USA