CYANOBACTERIAL TOXINS - Cyanobacteria - page 585

Holmes, C. F. B., and Boland, M. P. (1993) Inhibitors of protein phosphatase-1 and -2A; two of the major serine/threonine
protein phosphatases involved in cellular regulation. Current Opin Struct Biol 3: 934-943.
Honakanen, R. E., Codispoti, B. A., Tse, K., and Boynton, A. L. (1994) Characterization of natural toxins with inhibitory
activity against serine/threonine protein phosphatases. Toxicon 32: 339-350.
Honakanen, R. E., Zwiller, J., Moore, R. E., Daily, S. L., Khatra, B. S., Dukelow, M., and Boynton, A. L. (1990) Characterization
of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatase. J Biol Chem 265: 19401-19404.
Hooser, S. B., Beasley, V. R., Lovell, R. A., Carmichael, W. W., and Haschek, W. M. (1991) Actin fi lament alterations in rat
hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga, Microcystis aeruginosa .
Vet Pathol 28: 259-266.
Horecka, M., and Komarek, J. (1979) Taxonomic position of three planktonic blue-green algae from the genera Aphanizomenon
and Cylindrospermopsis . Preslia (Prague) 51: 289-312.
Hormazabal, V., Ostensvik, O., Underdal, B., and Skulberg, O. M. (2000) Simultaneous determination of the cyanotoxins
anatoxin A, microcystin desmethyl-3-RR, LR, RR and YR in water using liquid chromatography-mass spectrometry. J
Chromatogr Relat Technol 23: 3155-3164.
Hoshimoto, Y., Kamiya, H., Yamazato, K., and Nozawa, K. (1976) Occurrence of a toxic blue-green alga inducing skin dermatitis
in Okinawa. In: Ohsaka, A., Hayashi, K., and Sawai, Y. (Eds.) Animal , Plant and Microbial Toxins . Plenum Publishing,
New York, NY, USA. pp. 333-338.
Hotto, A. M., Satchwell, M. F., and Boyer, G. L. (2007) Molecular characterization of potential microcystin-producing
cyanobacteria in Lake Ontario Embayments and nearshore waters. Appl Environ Microbiol 73: 4570-4578.
Hrudey, S. E., Lambert, T. W., and Kenefi ck, S. L. (1994) Health risk assessment of microcystins in drinking water supplies. In:
Toxic Cyanobacteria-a Global Perspective . Australian Centre for Water Quality Research, Adelaide, Australia. pp. 7-12.
Hrudey, S., Burch, S., Burch, M., Drikas, M., Greorgy, R., (1999) Remedial measures. In: Chorus, I., and Bartram, J. (Eds.),
Toxic Cyanobacteria in Water . A Guide to their Public Health Consequences , Monitoring and Management . Routledge, London,
pp. 275-312.
Huber, C. S. (1972) The crystal structure and absolute confi guration of 2,9-diacetyl-9-azabicyclo[4,2,1]non-2,3-ene. Acta
Crystol 238: 2557-2582.
Hummert, C., Reichelt, M., and Luckas, B. (2000) New strategy for the determination of microcystins and diarrhetic
shellfi sh poisoning (DSP) toxins, two potent phosphatases 1 and 2A inhibitors and tumor promoters. J Anal Chem 366:
508-513.
Hummert, C., Reichelt, M., Weiss, J., Liebert, H. P., and Luckas, B. (2001) Identifi cation of microcystins in cyanobacteria from
the bleiloch former drinking-water reservoir (Thuringia, Germany). Chemosphere 44: 1581-1588.
Humpage, A. R., and Falconer, I. R. (1999) Microcystin-LR and liver tumor promotion: Effects on cytokinesis, ploidy, and
apoptosis in cultured hepatocytes. Environ Toxicol Water Qual 14: 61-75.
Humpage, A. R., Hardy, S. J., Moore, E. J., Froscio, S. M., and Falconer, I. R. (2000) Microcystins (cyanobacterial toxins) in
drinking water enhance the growth of aberrant crypt foci in the mouse colon. J Toxicol Environ Health 61: 155-165.
Humpage, A. R., Rositano, J., Bretag, A. H., Brown, R., Baker, P. D., Nicholson, B. C., and Steffensen, D. A. (1994) Paralytic
shellfi sh poisons from Australian cyanobacterial blooms. Aus J Mar Freshwater Res 45: 761-771.
Huot, R. I., Armstrong, D. I., and Chanh, T. C. (1989) In vitro and in situ inhibition of the sodium channel blocker STX by
monoclonal antibodies. J Toxicol Environ Health 27: 381-393.
Imanishi, S., Kato, H., Mizuno, M., Tsuji, K., and Harada, K.-I. (2005) Bacterial degradation of microcystins and nodularin.
Chem Res Toxicol 18: 591-598.
Ishida, K., and Murakami, M. (2000) Kasumigamide, an antialgal peptide from the cyanobacterium Microcystis aeruginosa .
J Org Chem 65: 5898-5900.
Ishida, K., Christiansen, G., Yoshida, W. Y., Welker, M., Bonjoch, J., Hertweck, C., Börner, T., Hemscheidt, T. K., and Dittmann,
E. (2007) Biosynthetic pathway and structure analysis of aeruginoside 126A and B, cyanobacterial peptides bearing an
unusual 2-carboxy-6-hydroxyoctaindole moiety. Chem Biol 14: 565-576.
Ishida, K., Matsuda, H., and Murakami, M. (1998) Four new microginins, linear peptides from the cyanobacterium Microcystis
aeruginosa . Tetrahedron . 54: 13475-13484.
Ishida, K., Okita, Y., Matsuda, H., Okino, T., and Murakami, M. (1999) Aeruginosins, protease inhibitors from the
cyanobacterium Microcystis aeruginosa . Tetrahedron. 55: 10971-10988.
Ishida, K., Welker, M., Christiansen, G., Cadel-Six, S., Bouchier, C., Dittmann, E., Hertweck, C., and Tandeau de Marsac, N.
(2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol 75: 2017-2026.
Ishii, H., Nishijima, M., and Abe, T. (2004) Characterization of degradation process of cyanobacterial hepatotoxins by a
gram-negative aerobic bacterium. Water Res 38: 2667-2676.
ISO 20179 (2005) Water Quality: Determination of microcystins-method by solid phase extraction (SPE) and high performance
liquid chromatography (HPLC) with ultraviolet (UV) detection. ISO, Geneva, Switzerland.