Biomedical Engineering Reference
In-Depth Information
6
Release-C
ontrolledCoatings
JamesZhengguiTangandNicholasP.Rhodes
CONTENTS
Introduction ................................................................................................................................. 260
Matrix Materials .......................................................................................................................... 261
Polymer-Based Matrix ........................................................................................................... 261
Nonerodible Polymeric Matrix........................................................................................ 262
Erodible Polymer Matrix .................................................................................................. 266
Inorganic-Based Matrix ......................................................................................................... 269
Ceramic-Coated Tacrolimus-Eluting Stent .................................................................... 269
Yukon Drug-Eluting Stent ................................................................................................ 270
Janus Carbostent™ ............................................................................................................ 270
Axxion Paclitaxel-Eluting Stent....................................................................................... 270
Genous™ Endothelial Progenitor Cell Capturing Stent .............................................. 270
Fully Erodible Metallic and Polymer Stents....................................................................... 271
Fully Polylactic Acid Stent ............................................................................................... 271
Biocorrodible Metallic Stents ........................................................................................... 272
Structures and Forming Techniques......................................................................................... 272
Passive Coating....................................................................................................................... 275
Active Coatings ...................................................................................................................... 276
A Single Layer Reservoir .................................................................................................. 276
Multiple-Layer Reservoir ................................................................................................. 278
Intra-Built Holes ................................................................................................................ 279
Intra-Built Cavity............................................................................................................... 279
Surface-Built Micro- and Nanoporous Membrane ....................................................... 280
Top Coat................................................................................................................................... 280
Coating Techniques................................................................................................................ 280
Dip Coating ........................................................................................................................ 280
Spray Coating..................................................................................................................... 281
Ink-Jet Technology............................................................................................................. 282
Controlled Release ...................................................................................................................... 283
Local Drugs ............................................................................................................................. 284
Controlled Release ................................................................................................................. 287
Diffusion-Controlled Release........................................................................................... 288
Dissolution/Degradation-Controlled Release .............................................................. 290
Perspectives of Release-Controlled Coatings.......................................................................... 292
References..................................................................................................................................... 295
259
