Environmental Engineering Reference
In-Depth Information
lished that maximum toxicity to all types of living species occurs with the
triorganotin compounds R
3
SnX. As the length of the carbon chain is progres-
sively increased within a particular series of tri-
n
-alkyltin salt, R
3
SnX, the
mammalian toxicity reaches a maximum value when R is an ethyl group, and
then falls off rapidly with further lengthening of the alkyl chain. The tri-
n
-
Table 3
Acute oral toxicity of organotin compounds [3, 14, 18, 24, 31]
LD
50
(rats, mg kg
-1
)
Compound
R
4
Sn
Me
4
Sn
195-331
Et
4
Sn
9-16
Bu
4
Sn
>
4000
Oct
4
Sn
>
4000
R
3
SnX
Me
3
SnCl
9-20
Me
3
SnOAc
9.1
Et
3
SnCl
10
Et
3
SnOAc
4.0
Pr
3
SnOCOMe
118
Pr
3
SnOSnPr
3
120
Bu
3
SnCl
122-349
Bu
3
SnF
200
Bu
3
SnOCOMe
125-136, 125-380
Bu
3
SnOCO(CH
2
)
9
Me
205
Bu
3
SnOCO(CH
2
)
7
CH = CH(CH
2
)
7
Me
195
Bu
3
SnOCOPh
132
Bu
3
SnOSnBu
3
112-234, 148-234
Oct
3
SnCl
>
4000
Oct
3
SnOCOMe
>
1000
Ph
3
SnCl
125, 125-135
Ph
3
SnF
1170, 160
Ph
3
SnOH
500-600, 108-360
Ph
3
SnOCOMe
125-491, 125-150
R
2
SnX
2
Me
2
SnCl
2
74-237
Et
2
SnCl
2
66-94
Bu
2
SnCl
2
112-219
Bu
2
SnO
487-520
Oct
2
SnCl
2
>
4000
Oct
2
SnO
2334-2350,
>
4000
RSnX
3
MeSnCl
3
575-1370
BuSnCl
3
2200-2300
OctSnCl
3
2400-3800
