Environmental Engineering Reference
In-Depth Information
Table 7
Minimum inhibitory concentration (MIC) for larval settlement and 30%lethal
concentration (LC
30
) values of 2,5,6-tribrom-1-methylgramine (TBG) and TBTO (ppm)
for reared cyprids [4]
Substance
MIC
LC
30
TBG
0.03
0.60
TBTO
0.20
0.06
4.2.2
Pyrrols
Pseudoceratidine
424
having 4,5-dibromopyrrole-2-carbamyl units, isolated
from a marine sponge
Pseudoceratina purpurea
, inhibited the larval settle-
ment and metamorphosis of a barnacle
Balanus amphitrite
with an ED
50
value of 8.0
gmL
-1
[29]. Further, in order to explore structure-activity re-
lationships responsible for antifouling and antimicrobial activity, Ponasik
et al. [30, 31] synthesized its several analogs. Of these compounds, 1,7-
diaminoheptane diamide (
425
) showed a much higher antifouling activity
with ED
50
value of 0.1
µ
gmL
-1
.
Another pyrrole compound, mauritiamine
426
isolated from a marine
sponge
Agelas mauritiana
, also showed moderate antifouling activity, and it
µ