Environmental Engineering Reference
In-Depth Information
Table 7 Minimum inhibitory concentration (MIC) for larval settlement and 30%lethal
concentration (LC 30 ) values of 2,5,6-tribrom-1-methylgramine (TBG) and TBTO (ppm)
for reared cyprids [4]
Substance
MIC
LC 30
TBG
0.03
0.60
TBTO
0.20
0.06
4.2.2
Pyrrols
Pseudoceratidine 424 having 4,5-dibromopyrrole-2-carbamyl units, isolated
from a marine sponge Pseudoceratina purpurea , inhibited the larval settle-
ment and metamorphosis of a barnacle Balanus amphitrite with an ED 50
value of 8.0
gmL -1 [29]. Further, in order to explore structure-activity re-
lationships responsible for antifouling and antimicrobial activity, Ponasik
et al. [30, 31] synthesized its several analogs. Of these compounds, 1,7-
diaminoheptane diamide ( 425 ) showed a much higher antifouling activity
with ED 50 value of 0.1
µ
gmL -1 .
Another pyrrole compound, mauritiamine 426 isolated from a marine
sponge Agelas mauritiana , also showed moderate antifouling activity, and it
µ
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