Neuroprotective Effects of Caffeine in Sleep Deprivation - Caffeine: Chemistry, Analysis, Function and Effects - page 300

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Figure 16.2 Chronic caffeine treatment prevents sleep deprivation-induced impair-

ment of synaptic plasticity of the dentate gyrus. Hippocampal long-term
potentiation (LTP) evoked by high-frequency stimulation applied to the
Schaffer collateral-commissural pathway of anesthetized rats. (A) Early-
phase LTP (E-LTP; evoked by HFS at zero time: arrow) in the DG area.
(B) Late-phase LTP (L-LTP; evoked by MHFS applied at time zero:
arrow) in area CA1. LTP was measured as increases in the slope of fEPSP
expressed as percentage of the baseline values (before stimulation). The
fEPSP slope values in the sleep-deprived rats are significantly lower than
those of control, caffeine, and caffeine-sleep deprivation groups at all
time points after stimulation, but chronic caffeine treatment prevents
fEPSP slope suppression. All the points between the two (*) are
significantly different from other groups (p,0.05). Insets are representa-
tive experiments; calibrations, 5 mV 5 ms 21 , apply to all traces. (Modified
from Alhaider et al 2010a; 2011, with permissions).