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Figure 14.1
Effect of caffeine on in vivo DA transmission in the Acb and PFCx.
Effect of intravenous administration of caffeine 0.25, 0.5, 1.0, 2.5 and
5.0 mg kg
21
(PFCx) and of caffeine 1.0, 2.5 and 5.0 mg kg
21
on AcbSh,
AcbC and PFCx DA transmission. Values are expressed as percentage
of baseline. Vertical bars represent S.E.M. Filled symbols indicate the
sample points significantly different from baseline (p,0.05).
Reproduced with permission from Acquas et al (2002), under Elsevier
and RightsLink licence no. 2720761155768.
To settle these discrepancies, in the AcbSh, obtained after systemic
administration of caffeine, it was concluded that these could be due to fine,
but quite critical, sub-regional differences in the localization of microdialysis
probes in the studies by Acquas et al (2002) and De Luca et al (2007) on one
hand and in those by Solinas et al (2002) and Borycz et al (2007) on the other.
It is now accepted that caffeine, at low doses, comparable to those reached by
dietary sources in humans, fails to stimulate DA transmission in the ventral
striatum (AcbSh and AcbC) and at least two lines of evidence might be
considered to support this interpretation.
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