Biomedical Engineering Reference
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Fig. 8.44
Results from 3D FSI model show negative correlation between wall thickness increase
(
WTI
) and plaque wall stress Stress-P1 (
PWS
), supporting 2D correlation results. (
a
) Real patient
scan at Time 1; (
b
) Patient scan at Time 2 (
10 month later
); (
c
) WTI vs. Stress-P1 (
3D
); (
d
) WTI
vs. Stress-P1 (
2D
) (
e
) Stress-P1 from 3D FSI Model; (
f
) Stress-P1 from 2D Model, the same slice.
(Image from Tang et al. 2008)
intimal thickening and atherosclerosis initiation. Despite this, intermediate and ad-
vanced plaques continue to grow under high shear stress conditions. The next ex-
ample is by Yang et al. (2010) which investigated the correlation of flow shear stress
with advanced plaque progression. The 3D models with FSI were created similarly
to the previous example where serial MRI data of carotid atherosclerotic plaques
were acquired 2-4times over an interval of 18 months with an example of the mod-
els shown in Fig.
8.45
. The material properties and boundary conditions make use
of the same profiles given earlier in Fig.
8.42
.
FSI models were constructed for 32 cases of the common carotid artery and in-
ternal carotid artery while the external carotid artery (ECA) was omitted because it
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