Biomedical Engineering Reference
In-Depth Information
1.7 Summary
Iron oxide nanoparticles hold great promise for many biomedical applications.
However, there are still some issues that need to be resolved before successful
clinical application of these nanoparticles for true molecular imaging. First, the
toxicity associated with the nanoparticles has to be addressed carefully before any
clinical applications. Some of the iron oxide nanoparticle derivatives can induce
several toxic effects, such as inflammation, the formation of apoptotic bodies,
impaired mitochondrial function, generation of reactive oxygen species and chro-
mosomal damage. Better control of the size distribution and minimizing non-
specific uptake by other organs has to be achieved for better clinical outcome.
Iron oxide nanoparticles are gathering much attention since they have potential
applications in drug delivery and noninvasive imaging. Therefore, therapy and
diagnosis can be achieved by one system. Due to this dual property, it is possible
to deliver image-guided therapy by combining two functionalities (diagnosis and
therapy) in clinical studies.
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