Biomedical Engineering Reference
In-Depth Information
Chapter 12
Integrating “Omics” Data for Quantitative
and Systems Pharmacology in Translational
Oncology
Erica L. Bradshaw Pierce and Aik Choon Tan
Abstract
Cancer is the phenotypic end point of multiple genetic aberrations and
epigenetic modifications that have accumulated within its genome. These genetic
and epigenetic alterations come together to form complex, dynamic, and plastic
networks that govern the “hallmarks of cancer.” The development of new
technologies and powerful computational algorithms to sequence and characterize
genomes have enabled researchers to acquire and analyze measurement of tens of
thousands of “omic” data points across these genetic and epigenetic changes within
cancer genomes. Quantitative and Systems Pharmacology (QSP) represents one of
these translational medicine approaches that integrates computational and experi-
mental methods to elucidate, validate, and apply new pharmacological concepts to
the development and use of small molecule and biologic drugs. QSP is a promising
approach that can provide a scientifically rational approach for defining optimal
multidrug regimens, identifying responsive patient populations, identifying transla-
tional biomarkers, and designing clinical trials.
E.L. Bradshaw Pierce
Department of Pharmaceutical Science, Skaggs School of Pharmacy, University of Colorado
Anschutz Medical Campus, Mail Stop C238, 12850 E. Montview Blvd., Rm 4107,
Aurora, CO 80045, USA
University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus,
Aurora, CO 80045, USA
e-mail:
erica.pierce@ucdenver.edu
A.C. Tan (
*
)
Division of Medical Oncology, Department of Medicine, School of Medicine,
University of Colorado Anschutz Medical Campus, Mail Stop 8117,
12801 E. 17th Avenue, RC1S-Rm8103, Aurora, CO 80045, USA
Department of Biostatistics and Informatics, Colorado School of Public Health,
University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus,
Aurora, CO 80045, USA
e-mail:
aikchoon.tan@ucdenver.edu
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