MODELS FOR COLLABORATIONS AND COMPUTATIONAL BIOLOGY - Collaborative Computational Technologies for Biomedical Research - page 47

Steering
Committee

Industry Scientific
Advisory Board

NIA

Administrative
Core

Executive
Committee

Genetics
Core

Biomarker
Core

Informatics
Core

Biostatistics
Core

MRI
Core

Clinical
Core

Neuropathology
Core

Coordination
Center

PET
Core

Acquisition
Sites

Figure 3.2 Schemata of organizational structure of Alzheimer's Disease Neuroimaging

Initiative (ADNI).

in the grant submission. The highly developed structure of ADNI has helped
to assure the success and productivity of this landmark public-private partner-
ship (PPP). Figure 3.2 depicts the multiple levels of oversight and the elaborate
organization that has enabled this PPP to be regarded as a successful example
of a large-scale consortium. For more detail see www.loni.ucla.edu/ADNI and
www.adni - info.org .

3.4.4 Osteoarthritis Initiative

The Osteoarthritis Initiative (OAI) is a multicenter, longitudinal, prospective
observational study of knee osteoarthritis. The initiative is coordinated by the
NIH's National Institute of Arthritis and Musculoskeletal and Skin Disease
(NIAMS) and the NIA. The overall goal of the OAI is to develop and put into
the public domain a research resource to expedite the evaluation of biomark-
ers for osteoarthritis as potential surrogate endpoints for disease onset and
progression.
To support the initial efforts of NIAMS and NIA, a public-private consor-
tium was established in 2002 to allow industry an opportunity to participate
in this initiative. The OAI consortium leverages public funding from the NIH