Biomedical Engineering Reference
In-Depth Information
21
PIONEERING USE OF THE
CLOUD FOR DEVELOPMENT
OF COLLABORATIVE DRUG
DISCOVERY ( CDD ) DATABASE
SEAN EKINS , MOSES M. HOHMAN , AND BARRY A. BUNIN
21.1
Introduction 336
21.2
Brief History of the Cloud 338
21.3
CDD Database Technical Details 339
21.3.1
Advantages of Cloud - Based Applications 342
21.4
Impact on Neglected Diseases 344
21.4.1
Malaria and Mtb 345
21.4.2
CDD TB DB and CDD Malaria DB as Examples of
Community Data Sharing and Evaluation 346
21.5
Pharmaceutical Companies Changing Their Business Model to Increase
Collaboration and Crowdsourcing 350
21.6
Future Directions of CDD Database 351
21.6.1
How to Build (Neglected) Disease Communities on the Cloud 351
21.6.1.1
Develop an Ontology to Facilitate Advanced Data Mining
Across CDD Databases 352
21.6.1.2
Collect, Mine, and Share Multiple Types of Data in CDD 353
21.6.1.3
Develop Alerts for Toxic/Reactive Functionality in small and
Large Molecules 354
21.7
Discussion 354
References 357
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