Biomedical Engineering Reference
In-Depth Information
Figure 16.8
Meta-analysis can be carried, as shown. Two cohorts are selected from
two studies which used the same platform to measure biomarkers. In this case gene
expression was measured in a set of breast and ovary tissues (a) and the
ESR1
gene
distribution is shown after
k
-means clustering is applied to the data set using
k
2
stratifying some breast tumor tissue samples (denoted as S1 …) as high expressors
(red) and as low expressors (blue) and similarly for the ovarian tumor tissue samples
(denoted as S2 … ).
=
Institute GeneChip Oncology Database [24], and other sources of gene expres-
sion data.
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16.7.3
Signatures
It is a very complex process to select the appropriate indication for an asset
in the development stage or even during life-cycle management. Many aspects
should be considered, such as a regulatory path for fi ling, potential market
size, differentiability of the therapeutic and experience with and diffi culty to
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