Biomedical Engineering Reference
In-Depth Information
TABLE 17.3
Anesthetic Drug Doses for Use in Nonhuman Primates
Drug(s)
Species
Dose
Duration
Antagonist
Comments
Ketamine Combinations e See
Table 17.2
Intravenous Agents
Propofol
Multiple
2e8 mg/kg i.v.
5e10 min
anesthesia,
10e15 min
sleep
none
Dose needed depends on level of prior
sedation
Marmoset
Bolus to effect i.v., followed
by 0.9 mg/kg/min
none
Required constant rate infusion dose varies
widely
Macaque
Bolus to effect i.v., followed
by 0.3e0.4 mg/kg/min
none
Volume infused may limit use as sole agent for
long procedures
Macaque
Bolus to effect i.v., followed
by 0.04e0.12 mg/kg/min
none
Co-administer a volatile agent or continuous
infusion of opioid (
Table 17.7
)
Alphaxalone
Marmoset
2e5 mg/kg bolus i.v.,
followed by 0.17
none
Preceded by sedation with ketamine or
alphaxalone i.m. (
Table 17.1
) Give bolus
slowly and repeat after 20e30 s if needed
0.003 mg/kg/min
Macaque
1e3 mg/kg bolus i.v.,
followed by 0.01e0.13 mg/
kg/min
none
Preceded by sedation with ketamine
midazolam (
Table 17.1
). Give bolus slowly
and repeat after 20e30 s if needed
