Biomedical Engineering Reference
In-Depth Information
TABLE 17.2
Immobilization Drug Doses for Use in Nonhuman Primates
Antagonist
a
Drug(s)
Species
Dose
Duration
Comments
Dissociative Agents and their Combinations
Ketamine
Multiple
5e25 mg/kg i.m. (smaller
species usually 15e25 mg/
kg, larger species usually
5e15 mg/kg)
30 min
None
Moderate sedation,
immobilization, some
analgesia
Ketamine: midazolam
Multiple
<
1 kg
15 mg/kg i.m.:
0.05e0.09 mg/kg i.v.
None: flumazenil
Immobilization, light to
moderate sedation
Multiple
1kg
5e15 mg/kg i.m.:
0.05e0.15 mg/kg i.v.
None: flumazenil
Immobilization, light to
moderate sedation
>
Ketamine: diazepam
b
Multiple
15 mg/kg i.m.: 0.3e1 mg/kg
i.m.
30e40 min anesthesia,
60e90 min sleep
None: flumazenil
Light surgical anesthesia
Ketamine: xylazine
Multiple
10: 0.15e0.25 mg/kg i.m.
30e40 min anesthesia,
60e120 min sleep
None: atipamezole
Sedation to light surgical
anesthesia
Can prolong anesthesia with
repeat doses
Multiple
10: 0.5 mg/kg i.m.
None: atipamezole
Surgical anesthesia
More difficult to maintain
normal physiological
parameters, cf above dose
Higher risk of bradycardia
and atrioventricular block,
cf above dose
Ketamine: medetomidine
Multiple
5: 0.05 mg/kg i.m.
30e40 min anesthesia,
60e120 min sleep
None: atipamezole
Light surgical anesthesia
Marmoset and tamarin
5: 0.1 mg/kg i.m.
None: atipamezole
Immobilization to deep
sedation
Macaque
2e5: 0.03e0.05 mg/kg i.m.
25e35 min
None: atipamezole
Sedation to light surgical
anesthesia
Baboon
5: 0.1 mg/kg i.m.
None: atipamezole
Immobilization to deep
sedation
Ketamine:
dexmedetomidine
Multiple
5e10 : 0.01e0.03 mg/kg
None: atipamezole
Sedation to light surgical
anesthesia
Ketamine: medetomidine
(OR dexmedetomidine):
buprenorphine
Macaque
5: 0.03(0.015): 0.01 mg/kg
None: atipamezole,
naloxone
Light surgical anesthesia
Good analgesia
Monitor for respiratory
depression
(Continued)
