Saturable Fractal Pharmacokinetics and Its Applications - Mathematical Methods and Models in Biomedicine - page 348

a

b

Fig. 6 Concentration-time curves for mibefradil data for Dog 3. ( a ) Log-log plot showing the
long-time power law tail from 30 min to 1,440 min. The dashed line is the regression line with
γ = − 024. ( b ) The same data but the dashed line now represents the best-fit curve found

using the steady state fractal model with X

0 . 597 ± 0 .

= 2 . 74

of 50 % polyoxyethylated castor oil (Cremophor EL) and 50 % dehydrated alcohol
(USP) [ 60 ]. It is usually administered by intravenous infusion. Paclitaxel binds
preferentially to microtubules, which are cellular components necessary for mitosis,
intracellular transport, maintenance of cell shape, and cellular motility. It has been
found to strongly inhibit cell replication by blocking cells in the G2 mitotic phase by