Pathogen Detection Using Magnetoelastic Biosentinels - Biomedical Engineering Systems and Technologies - page 56

4 Conclusions

New magnetoelastic sentinel technologies under development will lead to a plethora
of devices for food safety, biosecurity, environmental monitoring, and medical care.
Biosentinels composed of magnetically soft resonator platforms coated with a biore-
cognition layer such as phage or antibodies can wirelessly and remotely detect the
binding and capture of specific pathogenic bacteria. Magnetic propulsion and naviga-
tion of magnetoelastic biosentinels offers the potential for targeted medical therapeu-
tics and diagnostics that can open new avenues of treatment, increase the efficacy of
existing medical procedures, and improve the overall quality of health care.

References

1. Wetzel, B., Schaefer, H.: National Cancer Institute (1982)
2. Ballantine Jr., D.S., White, R.M., Martin, S.J., Ricco, A.J., Zellers, E.T., Frye, G.C.,
Wohltjen, H.: Acoustic Wave Sensors: Theory, Design, & Physico-Chemical Applications.
Academic Press, San Diego (1996)
3. Vellekoop, M.J.: Acoustic Wave Sensors and their Technology. Ultrasonics 36, 7-14
(1998)
4. Cooper, M.A., Singleton, V.T.: A Survey of the 2001 to 2005 Quartz Crystal Microbalance
Biosensor Literature: Applications of Acoustic Physics to the Analysis of Biomolecular In-
teractions. J. Mol. Recognit. 20, 154-184
5. Becker, B., Cooper, M.A.: A Survey of the 2006-2009 Quartz Crystal Microbalance Bio-
sensor Literature. J. Mol. Recognit. 24, 754-787 (2011)
6. Dixon, M.C.: Quartz Crystal Microbalance with Dissipation Monitoring: Enabling Real-
Time Characterization of Biological Materials and their Interactions. J. Biomol. Tech. 19,
151-158 (2008)
7. Hansen, K.M., Thundat, T.: Microcantilever Biosensors. Methods 37, 57-64 (2005)
8. Buchapudi, K.R., Huang, X., Yang, X., Ji, H.-F., Thundat, T.: Microcantilever Biosensors
for Chemicals and Bioorganisms. Analyst. 136, 1539-1556 (2011)
9. Li, S.Q., Orona, L., Li, Z., Cheng, Z.-Y.: Biosensor Based on Magnetostrictive Microcanti-
lever. Appl. Phys. Lett. 88, 73507 (2006)
10. Xie, F., Yang, H., Li, S.Q., Shen, W., Wan, J., Johnson, M.L., Wikle, H.C., Kim, D.-J.,
Chin, B.A.: Amorphous Magnetoelastic Sensors for the Detection of Biological Agents.
Intermetallics 17, 270-273 (2009)
11. Huang, S., Hu, J., Wan, J., Johnson, M.L., Shu, H., Chin, B.A.: The Effect of Annealing
and Gold Deposition on the Performance of Magnetoelastic Biosensors. Mater. Sci. Eng.,
C. 28, 380-386 (2008)
12. Shen, W., Mathison, L.C., Petrenko, V.A., Chin, B.A.: Design and Characterization of a
Magnetoelastic Sensor for the Detection of Biological Agents. J. Phys. D: Appl. Phys. 43,
15004 (2010)
13. Stoyanov, P.G., Grimes, C.A.: A Remote Query Magnetostrictive Viscosity Sensor. Sens.
Actuators, A. 80, 8-14 (2000)
14. Cheng, Z.-Y., Li, S.Q., Zhang, K.W., Fu, L.L., Chin, B.A.: Novel Magnetostrictive Micro-
cantilever and Magnetostrictive Nanobars for High Performance Biological Detection.
Adv. Sci. Technol. 54, 19-28 (2008)