Pathogen Detection Using Magnetoelastic Biosentinels - Biomedical Engineering Systems and Technologies - page 49

ME biosentinels have u
resonator platform and the
devices, enabling in-situ re
Due to its wireless nature, a
ly, which significantly enh
More importantly, the bind
can be easily detected. By
phage-coated ME resonator
blood cells can be built and
or water quality application

nique advantages that stem from both the magnetoela
phage biorecognition layer. The biosentinels are wirel
emote detection of multiple target pathogens (Figure
a large number of sentinels can be deployed simultaneo
hances the probability of binding with a target pathog
ding of target pathogens on only one out of many sentin
y taking advantage of these properties and capabilities
rs, a system of sentinels that mimics the functions of wh
d deployed for enhanced medical diagnostics, food saf
ns.

astic
less
3).
ous-
gen.
nels
s of
hite
fety,

and
mul-

Fig. 3. A large number of sen
interrogated simultaneously fo
taneously since the sentinels ar

ntinels targeting different pathogens may be mixed together
or pathogen detection. Different pathogens may be detected sim
re designed to operate in different frequency ranges.

One of the key paramete
low bacterial concentration
the number of ME sentinels
ronment. For detection in li
the media past the immobil
While flow cells are a viab
to harness the magnetic fie
the forces for motion to pro

ers of these biosentinels is the minimum detection limit.
ns, the odds of detection are improved either by increas
s deployed or by exposing the sentinels to a dynamic en
iquid media, dynamic exposure can be achieved by flow
ized sentinels or by moving the sentinels within the me
ble option, another approach to achieve greater exposur
eld that is currently used only for interrogation to prov
opel and steer the sentinels (Figure 4).

. At
sing
nvi-
wing
dia.
re is
vide

enerated by the detection system can induce sentinel movemen Fig. 4. The magnetic field ge nt