Biomedical Engineering Reference
In-Depth Information
This workspace enables searching, filtering, browsing and viewing all collected
data in a typical web interface. Moreover, researchers can combine data and down-
load it for personal usage.
Along with the web interface for researchers, Oralome encompasses a set of web
services for programmatic data access. Oralome's API is available for R, HTTP,
REST and SOAP. These interfaces enable any developer to build custom solutions
using any development framework, using Oralome's curated data related to the oral
cavity.
In addition to the described oral cavity data exploration scenarios, Oralome allows
the deployment of an unlimited number of customized applications. Using any of the
remote API interfaces, developers can use Oralome data to enrich already existing
applications or to develop new ones.
This key Oralome feature envisages the use of collected curated oral cavity infor-
mation in education scenarios or by medical dentists. Oralome web framework's
openness will enable the creation of an entire application ecosystem built around ex-
pertly curated information, aiming for the delivery of improved dental health care.
4.2
Oralcard Interface
OralCard web application is available online at http://bioinformatics.ua.pt/oralcard.
The researcher is first presented with a home page where he can insert search items.
These can be related to proteins, diseases or microorganisms. Each of these entities
has dedicated views, where the user can find answers to several questions.
The OralCard web application can provide the user with information about:
•
Diseases involved in a specific saliva protein;
•
Salivary proteins involved in a specific disease;
•
Proteins whose levels are altered in a specific disease;
•
Proteins obtained from a particular source (which ones and how many);
•
Microorganisms involved in a particular disease;
•
Diseases in which a particular microorganism is evolved;
•
Proteins produced by a given microorganism and present in a certain disease;
Fig. 4 shows the dedicated view for the
Neutrophil collagenase
protein. The user is
presented with a list of choices, where he can consult related diseases, Protein Data
Bank structures, PubMed references and the related sources. We also embed some
online tools, like UniProt, Panther or BRENDA, in order to facilitate access to specif-
ic information provided by these services.
5
Evaluation
As an example of application, we used the Oralome tool to evaluate how saliva pro-
teins contribute to or reflect impaired healing of oral cavity tissues in diabetic patients
[29]. Then we identified all the salivary proteins whose amount is changed in patients
with diabetes mellitus.
Search WWH ::
Custom Search