Biomedical Engineering Reference
In-Depth Information
0
-1
-2
-3
-4
Penciclovir
Vidarabine
-5
-6
-7
0
2
4
6
8
10
12
14
pH
b
7
6
5
4
3
2
Accepted CS/QC
Rejected CS/QC
1
0
0
50
100
150
200
Sample Sequence No.
c
14
12
10
8
6
4
2
0
50
100
150
200
Sample Sequence No.
Fig. 14
(
a
,
top
): Hydrophobicity (log
D
) vs. pH curves for penciclovir and vidarabine. (
b
,
middle
):
Less internal standard response variation was observed while using vidarabine as the internal stan-
dard (CV = 13.02 %) but 43 % of the calibration standards (CS) and quality controls (QC) were
rejected. Extraction: MCX (mixed-mode strong cation exchange)-based solid-phase extraction.
(
c
,
bottom
): More IS response variation was observed while using a deuterated internal standard,
penciclovir-d
4
(CV = 23.81 %) but 100 % of the CS and QC samples were accepted. Reproduced
from ref. [
36
] with permission from Elsevier
