Biomedical Engineering Reference
In-Depth Information
At least, extended compound/spectra data bases especially for ESI that allow
adequate fitting and search algorithms will help to improve identification of unknown
analytes relevant for toxicological and forensic samples.
To conclude, TA analysis by LC-MS methods will benefit from general technical
progress in the near future allowing to obtain more rapid and exact data for qualita-
tive and quantitative measurement.
References
1. Grynkiewicz G, Gadzikowska M (2008) Tropane alkaloids as medicinally useful natural
products and their synthetic derivatives as new drugs. Pharmacol Rep 60:439-463
2. Li F, Sun S, Wang J, Wang D (1998) Chromatography of medicinal plants and Chinese traditional
medicine. Biomed Chromatogr 12:78-85
3. Cook EB, Dennis M, Ochillo RF (1981) Application of thin layer, ion exchange, and high
performance liquid chromatography to separate pharmacologically active components of an
African arrow poison of plant origin. J Chromatogr 4:549-557
4. Zhu L, Yang LM, Cui YY, Zheng PL, Niu YY, Wang H, Lu Y, Ren QS, Wei PJ, Chen HZ
(2008) Stereoselectivity of satropane, a novel tropane analog, on iris muscarinic receptor
activation and intraocular hypotension. Acta Pharmacol Sin 29:177-184
5. Chen H, Chen Y, Du P, Han F (2007) Structural elucidation of in vivo and in vitro metabo-
lites of anisodine by liquid chromatography-mass spectrometry. J Pharm Biomed Anal
44:773-778
6. Chen Y, Du P, Han F, Chen H (2007) Characterization of in vivo and in vitro metabolic path-
way of anisodamine by liquid chromatography-tandem mass spectrometry. J Liq Chromatogr
Rel Technol 30:1933-1949
7. Chen H, Chen Y, Wang H, Du P, Han F, Zhang H (2005) Analysis of scopolamine and its
eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry.
Talanta 67:984-991
8. Balunas MJ, Kinghorn AD (2005) Dug discovery from medicinal plants. Life Sci
78:431-441
9. Christen P (2000) Tropane alkaloids: old drugs used in modern medicine. In: Rahman A (ed)
Studies in natural products chemistry, vol 22, bioactive natural products (part C). Elsevier,
Amsterdam
10. Ali-Melkkilä T, Kanto J, Isalo E (1993) Pharmacokinetics and related pharmacodynamics of
anticholinergic drugs. Acta Anaesthesiol Scand 37:633-642
11. Beyer J, Peters FT, Kraemer T, Maurer HH (2007) Detection and validated quantification of
toxic alkaloids in human blood plasma - comparison of LC-APCI-MS with LC-ESI-MS/MS.
J Mass Spectrom 42:621-633
12. Sauvage FL, Gaulier JM, Lachatre G, Marquet P (2008) Pitfalls and prevention strategies for
liquid chromatography-tandem mass spectrometry in the selected reaction-monitoring mode
for drug analysis. Clin Chem 54:1519-1527
13. Bjornstad K, Hulten P, Beck O, Helander A (2009) Bioanalytical and clinical evaluation of
103 suspected cases of intoxications with psychoactive plant materials. Clin Toxicol
47:566-572
14. Gerber R, Naude TW, de Kock SS (2006) Con fi rmed Datura poisoning in a horse most prob-
ably due to D. ferox in contaminated tef hay. J S Afr Vet Assoc 77:86-89
15. Steenkamp PA, Harding NM, van Heerden FR, van Wyk BE (2004) Fatal Datura poisoning:
identification of atropine and scopolamine by high performance liquid chromatography/
photodiode array/mass spectrometry. Forensic Sci Int 145:31-39
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