Biomedical Engineering Reference
In-Depth Information
Table 5
Tropane alkaloid analysis in plasma or serum by LC-MS and LC-MS/MS for pharmacokinetic studies
Ionization/mass
analyser/scan mode
Analyte
Column (mm × mm)/ fl ow (ml/min)/
T
(°C) Mobile phase
a
(run mode)
Lin range (ng/ml)
b
Reference
Atr
X-Terra MS C8 (100 × 2.1)/0.2/n.s.
Solv A: ACN
Solv B: 2 mM NH
4
FA, pH 3.0 (gradient)
0.25-50
+ESI/QqQ/MRM
[
44
]
Atr,
R
-/
S
-Hyo Atlantis T3 C18 (150 × 4.6)/1.0/30
Solv A: 0.1 % v/v FA
Solv B: ACN/0.1 % FA 80:20 (gradient)
0.1-50
+ESI/QqQ/MRM
[
47,
49
]
BuS
C18 n.s. (50 × 4.6)/0.45/40
Solv. A: ACN
Solv. B: 5 mM NH
4
OAc, 0.1 % FA, 60:40
(iso)
0.1-40
+ESI/QqQ/MRM
[
79
]
Cim
YMC Hydrosphere C18 (50 × 2)/0.2/35
MeOH/10 mM NH
4
OAc, pH 4.0, 81:19
(iso)
0.2-100
+ESI/QqQ/MRM
[
61
]
Gran
Lichrospher C18 (50 × 4.6)/1.0/30
10 mM NH
4
OAc, 0.5 % HOAc in ACN/
H
2
O 40:60 (iso)
0.02-20
+ESI/QqQ/MRM
[
71
]
Gran
Xterra MS (150 × 2.1)/0.2/40
H
2
O/ACN/10 mM NH
4
OAc, pH 3.5,
27:23:50 (iso)
5-1,000
+ESI/SQ/SIM
[
72
]
Gran
Symmetry C18 (150 × 4.6)/1.0/30
0.03 % FA/ACN 30:70 (iso)
0.1-20
+ESI/QqQ/MRM
[
73
]
Ipra
c
RP DB-8 (75 × 3)/0.7/25
Solv A: 10 mM NH
4
OAc, pH 3.0
Solv B: ACN (gradient)
10-100
+ESI/IT/MS
[
24
]
R
-/
S
-Hyo
Chirobiotic V (250 × 4.6)/1.0/30
MeOH/HOAc/Et
3
N 100:0.05:0.04
(gradient)
0.5-50
+APCI/SQ/SIM
[
48
]
Scp
d
Purospher STAR RP-18e (55 × 2)/0.3 or
0.4/n.s.
Solv A: ACN/2 mM NH
4
OAc/FA 5:95:0.2
Solv B: ACN/2 mM NH
4
OAc/FA 95:5:0.2
(gradient)
Serum: 0.02-5
Dial.: 0.05-10
+ESI/QqQ/MRM
[
97-
99
]
Scp
n.s./n.s./n.s.
n.s.
0.02-0.5
n.s.
[
88
]
Scp
Sun fi re C18 (250 × 4.6)/0.3/n.s.
10 mM NH
4
OAc, pH 4.0/MeOH/ACN
30:40:30 (iso)
10-2,000
+ESI/SQ/SIM
[
89
]
Tio
Zorbax Extend C18 (150 × 4.6)/0.8/30
ACN/10 mM NH
4
OAc, 1 % FA 40:60 (iso) 0.0005-0.05
+ESI/QqQ/MRM
[
80
]
(continued)