Biomedical Engineering Reference
In-Depth Information
16.15
15.00
18.41
17.85
19.80
19.18
22.92
22.15
m/z 251, M-7
100
m/z 261, D
10
-M-7
80
m/z 261, M-5
m/z 289, D
10
-M-5
60
m/z 320, M-8
40
m/z 330, D
10
-M-8
17.85
20
m/z 330, M-9
m/z 330, D
10
-M-9
0
5
10
15
Time (min)
20
25
30
Fig. 5
Reversed-phase LC separation of pibutidine metabolites and their corresponding deuterium-
labeled analogues. Reproduced from ref. [
33
] with permission from Elsevier
Fig. 6
Profile of postcolumn infusion of carvedilol with an injection of control plasma extract
(lot 3, the problematic lot) overlaid with the LC-MS/MS chromatograms of carvedilol and its
deuterated internal standard (D
5
-carvediol) to demonstrate a significant difference in ion suppres-
sion (~25 %) due to even a very small difference in retention time (0.02 min) between carvediolol-S
(1.93 min) and its deuterated internal standard (1.91 min). Reproduced from ref. [
35
] with permission
from Elsevier
