Biomedical Engineering Reference
In-Depth Information
Table 2
Description and performance of the reported methods for quantification of TKIs
Volume of biological
sample
Accuracy at LOQ
(% bias)
Precision at LOQ
(CV%)
Drugs analyzed
Analytical method
LOQ (ng/ml)
Reference
Imatinib
200 m l Human plasma
ESI-TSQ
10
−14.7
5.27
Titier et al. [
110
]
Imatinib
200 m l Human plasma
ESI-TSQ
10
1.68
5.75
Awidi et al. [
103
]
Imatinib
250 ml Human red blood cells
plasma
ESI-TSQ
2.1
1.8
−4.3 to 0.8
0.2 to 2
3.78 to 5.02
5.74 to 2.39
Guetens et al. [
106
]
Imatinib
200 ml Whole human blood
and leukemia cells
Turbo ion
spray-TSQ
0.03
0.9
−1.9
8.8
13.2
Klawitter et al. [
107
]
Imatinib and
CGP 74588
1
2
-
-
Boddy et al. [
105
]
200 ml human plasma
ESI-TSQ
Imatinib and
CGP 74588
ESI-single
quadrupole
30
-
-
Parise et al. [
108
]
200 ml human plasma
Imatinib and
CGP 74588
1
-
-
Rochat et al. [
109
]
100 ml human plasma
ESI-TSQ
Imatinib and
CGP 74588
4
−0.8 to 4
4.19 to 5.64
Bakhtiar et al. [
104
]
200 ml human plasma
ESI-TSQ
Nilotinib
200 ml Human plasma
Serum
ESI-single
quadrupole
5
−7.9
1.6
3.6
7.8
Parise et al. [
111
]
Nilotinib
100 m l Human serum
ESI-TSQ
2.5
-
-
Tanaka et al. [
112
]
Dasatinib
100 m l Human plasma
ESI-linear trap
-
-
-
Christopher et al. [
126
]
Bosutinib
100 ml Human plasma
Turbo ion
spray-TSQ
1
-
-
Abbas et al. [
88
]
Sunitinib
200 m l Human plasma
ESI-TSQ
0.6
-
-
Minkin et al. [
114
]
Sunitinib
100 m l Human plasma
ESI-TSQ
0.2
9.5
11.7
De Bruijn et al. [
113
]
Sorafenib
50 m l Human plasma
ESI-TSQ
5
−4.33
7.45
Jain et al. [
115
]
Sorafenib
100 m l Human plasma
ESI-TSQ
7.3
2.3
3.3
Zhao et al. [
116
]
Lapatinib
100 ml Human plasma
Turbo ion
spray-TSQ
15
-
11
Bai et al. [
117
]
