Biomedical Engineering Reference
In-Depth Information
Concentrations expected
following therapeutic use (mg/L)
Drug
t
1/2
(h)
a
V
D
(L/kg)
b
Fb
c
9-OH-Risperidone
0.01-0.1
23
U/K
U/K
Amisulpride
0.05-0.4
11-27
13-16
0.17
Aripiprazole
0.05-0.35
60-90
4.9
0.99
Bromperidol
0.001-0.02
15-35
U/K
U/K
Buspirone
0.001-0.01
3-12
5-6
0.95
Chlorpromazine
0.03-0.3
7-119
10-35
0.98
Chlorprothixene
0.02-0.2
8-12
11-23
U/K
Clozapine
0.2-0.8
6-17
2-7
0.95
Droperidol
0.005-0.05
1.3-2.7
1.5-2.5
0.85-0.90
Flupentixol
0.001-0.015
19-39 (HCl)
14.1
U/K
5-113 days (decanoate)
Fluphenazine
0.002-0.02
13-58 (HCl)
220
0.99
3-4 days (enanthate)
5-12 days (decanoate)
Fluspirilene
U/K
21 days
U/K
U/K
Haloperidol
0.005-0.05
14-41 (lactate)
18-30
0.90
14-28 (decanoate)
Levomepromazine
0.015-0.06
15-30
30
U/K
Loxapine
0.01-0.1
3-4
U/K
0.91-0.99
Melperone
0.05-0.4
2-4
7-10
U/K
Mesoridazine
0.15-1
2-9
3-6
0.99
Molindone
~0.5
1.2-2.8
3-6
U/K
Olanzapine
0.01-0.1
21-54
10-20
0.93
Pen fl uridol
0.004-0.025
Perazine
0.1-0.23
8-15
U/K
0.96
Pericyazine
0.005-0.06
U/K
U/K
U/K
Perphenazine
0.0006-0.0024
8-12
10-35
>0.90
Pimozide
0.015-0.02
28-214
11-62
0.99
Pipamperone
0.1-0.4
12-30
U/K
U/K
Prochlorperazine
0.01-0.5
14-27
13-32
>0.90
Promazine
0.01-0.4
7-17
27-42
0.84
Promethazine
0.05-0.4
10-20
9-19
0.93
Quetiapine
0.07-0.17
2.7-9.3
8-12
0.83
Risperidone
0.01-0.1
3-20
0.7-2.1
0.90
Sertindole
0.05-0.5
U/K
20-40
0.99
Sulpiride
0.05-0.4
4-11
2.7
0.40
Thioridazine
0.2-2
26-36
18
0.96
Thiothixene
U/K
12-36
U/K
0.91-0.99
Tri fl uoperazine
0.001-0.05
7-18
U/K
>0.90
Tri fl uperidol
U/K
U/K
U/K
U/K
Tri fl upromazine
0.03-0.1
U/K
U/K
U/K
Ziprasidone
0.05-0.12
2-8
1.5-2.3
0.99
Zotepine
0.005-0.3
12-30
50-168
0.97
Zuclopenthixol
0.005-0.1
12-26 (HCl)
15-20
0.98
18-24 (acetate)
19 days (decanoate)
a
Terminal elimination half-life
b
Volume of distribution
c
Blood to plasma concentration ratio
U/K = unknown
