Biomedical Engineering Reference
In-Depth Information
Amitriptyline
Clomipramine
Imipramine
Cl
N
N
H
3
C
H
3
C
H
3
C
N
N
N
H
3
C
H
3
C
H
3
C
Sertraline
Fluoxetine
Doxepin
O
CH
3
CH
3
HN
O
Cl
H
3
C
F
F
N
Cl
H
3
C
F
Paroxetine
Venlafaxine
Citalopram
CH
3
O
O
N
CH
3
H
CH
3
N
HO
O
H
3
C
O
CH
3
O
N
F
Trazodone
Duloxetine
Bupropion
Cl
S
O
NH
CH
3
CH
3
Cl
NH
CH
3
N
N
O
N
CH
3
CH
3
N
N
O
Fig. 1
Chemical structure of some antidepressants commonly used in clinical practice
noradrenalin reuptake inhibitors (SNaRIs), noradrenergic and specific serotoniner-
gic antidepressants (NaSSAs), and noradrenalin reuptake inhibitors (NaRIs).
Figure
1
shows the chemical structures of some of the most common antide-
pressants used in clinical practice.
The main indication for antidepressants is depressive disorders, which have
received increased attention owing to the growing recognition of their high preva-
lence. Other antidepressant uses include treatment of anxiety disorders, attention
deficit hyperactivity disorders, nocturnal enuresis or psychosomatic disorders
