Biomedical Engineering Reference
In-Depth Information
Chondroitin Sulfate Surface Engineered
Docetaxel-Loaded Liposomes for Tumor
Targeting: Design, Development,
and Characterization
Aditya Ganeshpurkar, Ankit Ganeshpurkar, Abhishek Agnihotri,
Vikas Pandey, Nikhar Vishwakarma, Divya Bansal
and Nazneen Dubey
Abstract Cancer is amongst the most devastating uncontrolled cellular growth that
hampers the growth of normal cells leading to their malfunctioning and organ
failure. Anticancer agents are widely used to limit the progression of cancer;
however, it suffers from severe side effects. Development of novel modes of drug
delivery has minimized the side effects and has increased the therapeutic index of
drugs. In the current work, chondroitin sulfate-coupled liposomes of docetaxel were
prepared and characterized. The formulation was also studied for in vivo efficacy
and biodistribution. The formulation effectively enhanced the life period of exper-
imental animals, which reflects the success of formulation. Thus, use of chondroitin
sulfate-coupled docetaxel-loaded liposomes could be advocated to treat cancer.
However, systemic in vivo studies are required to extrapolate its effects on humans.
Keywords Surface engineered liposomes
Chondroitin sulfate
Docetaxel
Tumor targeting
Introduction
Cancer is characterized by the rapid growth of abnormal cells. Various external
and internal factors predispose to progression of cancer [
1
]. Currently, along with
new drug discovery, development of a suitable carrier system becomes essential to
A. Ganeshpurkar (
&
)
A. Ganeshpurkar
A. Agnihotri
N. Vishwakarma
N. Dubey
Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy,
Jabalpur, Madhya Pradesh, India
V. Pandey
D. Bansal
Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy,
Jabalpur, Madhya Pradesh, India
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