Biomedical Engineering Reference
In-Depth Information
Table 4.1 Core PCP genes and their modulators—cont'd
Drosophila PCP
gene
Vertebrate gene
Species
Molecular features
Cell movements
References
rho kinase 2
(
rok2
)z
Rho kinase
(
drok
)
Serine/threonine
kinase, RhoA
effector
CE
Marlow et al. (2002)
jun N-terminal
kinase
(
jnk
)
X
Serine/threonine
kinase
CE
Yamanaka et al. (2002)
,
Schambony
and Wedlich (2007)
,
Oishi et al.
(2003)
CE
†
, NTD
int
X
inturned
(
in
)
Putative PDZ
domain
Park et al. (2006)
4-pass TM protein CE
†
, NTD
fy
X
fuzzy
(
fy
)
Park et al. (2006)
ror2
X
Receptor tyrosine
kinase, Wnt5
receptor
CE
Schambony and Wedlich (2007)
,
Oishi et al. (2003)
,
Hikasa et al.
(2002)
paraxial
protocadherin
(
papc
)
X
Protocadherin
CE
Medina et al. (2004)
,
Unterseher
et al. (2004)
,
Wang et al. (2008)
neurotrophin
receptor homologue
1
(
NRH1
)
X
Receptor tyrosine
kinase
CE
Sasai et al. (2004)
,
Chung et al.
(2005)
ptk7
X, m
Receptor tyrosine
kinase
NTD
Lu et al. (2004)
,
Paudyal et al. (2010)
Cthrc1
m
Wnt cofactor
NTD*
Yamamoto et al. (2008)
