Biomedical Engineering Reference
In-Depth Information
Table 4.1 Core PCP genes and their modulators
Drosophila PCP
gene
Vertebrate gene
Species
Molecular features
Cell movements
References
wnt11
z, X
Secreted Wnt
glycoprotein
CE, NC
Heisenberg et al. (2000)
,
Tada and
Smith (2000)
,
Carmona-Fontaine
et al. (2008)
wnt5b
z
Secreted Wnt
glycoprotein
CE, JC
Rauch et al. (1997)
wnt5a
X
Secreted Wnt
glycoprotein
CE, NC
Yamanaka et al. (2002)
,
Oishi et al.
(2003)
,
Matthews et al. (2008)
vangl2
z, X, m, c
strabismus/Van
Gogh
(
vang
)
4-pass TM protein CE, NTD, NM,
CO, PS
Darken et al. (2002)
,
Goto and Keller
(2002)
,
Park and Moon (2002)
,
Kibar et al. (2001)
,
Murdoch et al.
(2001)
,
Jessen et al. (2002)
,
Montcouquiol et al. (2003)
,
Bingham et al. (2002)
,
Wang et al.
(2005)
,
Voiculescu et al. (2007)
glypican4 (gpc4)
z, X
Heparan sulfate
proteoglycan
CE, JC
Topczewski et al. (2001)
,
Ohkawara
et al. (2003)
,
LeClair et al. (2009)
dsh
/
Dvl1
/
2
z, X, m, c
disheveled
(
dsh
)
DIX, PDZ, and DEP
domains
CE, NTD, CO,
NM, PS, NC
Sokol (1996)
,
Hamblet et al. (2002)
,
Wang, Hamblet, et al. (2006)
,
Voiculescu et al. (2007)
,
Matthews
et al. (2008)
,
Carmona-Fontaine
et al. (2008)
fzd3
/
6
z, m
frizzled
(
fz
)
7-pass TM protein,
Wnt receptor
NTD, NM
Wang, Guo, et al. (2006)
,
Wada et al.
(2006)