Biomedical Engineering Reference
In-Depth Information
B
A
C
D
Figure 4.1 Different types of cell movements. (A) Collective cell migration in which cells
move individually (e.g., neural crest cells). Cells are loosely associated with each other
andmigrate in a uniformdirection. (B) Collective cell migration as a cohesive clump (e.g.,
prechordal plate progenitors). Cells are tightly packed and migrate in one direction
without changing neighbors. Cells at the leading edge (blue) form actin-based protru-
sions (shown in gray). (C) Cell intercalation mediated by formation and resolving of
rosette (e.g., Drosophila germband). Five or more cells meet at one point (“rosette” for-
mation) and resolve to make a new cell-cell boundary in relation to the direction of their
movement. (D) Cell intercalation in convergent extension (e.g., notochord progenitors).
Cells intercalate mediolaterally to simultaneously narrow and elongate the tissue along
the anteroposterior axis.
