The frizzled/stan Pathway and Planar Cell Polarity in the Drosophila Wing - Current Topics in Developmental Biology - page 1

CHAPTER ONE

The frizzled/stan Pathway and
Planar Cell Polarity in the
Drosophila Wing

Paul N. Adler * , † ,1
*Biology Department, University of Virginia, Charlottesville, Virginia, USA
†

Cell Biology Department, University of Virginia, Charlottesville, Virginia, USA
1 Corresponding author: e-mail address: [e-mail]

Contents
1. Introduction to Drosophila Planar Cell Polarity 2

2. The Cellular Basis for PCP 3

2.1 Epidermal hairs and the fly wing 3

2.2 Sensory bristles 3

2.3 The eye 4

2.4 Other manifestations of PCP 7

2.5 PCP that is not fz/stan pathway dependent 9

3. PCP Genes 9

3.1 Early studies on the fz/stan pathway 9

3.2 ds/ft pathway 12

3.3 Septate junction proteins 13

3.4 Other genes that impact PCP 14

3.5 Genome-wide screen for PCP genes 15

4. What is the Basis for the Asymmetric Localization of fz/stan Pathway Proteins? 16

4.1 Interactions of transmembrane proteins 17

4.2 Intracellular proteins 18

4.3 Wnts in fly PCP? 18

4.4 Mechanisms for the formation of PCP protein complexes 18

4.5 mRNA localization? 19

4.6 Directional trafficking and trapping 19

5. Directional Cell Nonautonomy 20

5.1 The basis for directional cell nonautonomy 20

6. Downstream Effectors 22

6.1 Planar polarity effector genes 22

6.2 mwh 22

6.3 A distal target of Dsh? 23

Acknowledgments 24

References 24

Note added in Proof 31