Biomedical Engineering Reference
In-Depth Information
for their membrane insertion as well as for proper targeting of partner proteins.
This raises the question of the role of putative proteins assisting in folding, like
receptor-activating protein RAP does for the lipoprotein receptor family
(
Herz, 2006
), or the beta-2 microglobulin for major histocompatibility
complexes (
Hansen, Connolly, Gould, & Fremont, 2010
). Would Celsr,
Fzd, and Vangl help each other's folding and complex formation in the
endoplasmic reticulum and traffic as a complex to the Golgi and to the
membrane, or are they assisted by other unidentified partners, and what
would be the role of chaperonins in the process?
REFERENCES
Adler, P. N. (2002). Planar signaling and morphogenesis in Drosophila.
Developmental Cell
,
2
,
525-535.
Bastock, R., Strutt, H., & Strutt, D. (2003). Strabismus is asymmetrically localised and binds
to Prickle and Dishevelled during Drosophila planar polarity patterning.
Development
,
130
, 3007-3014.
Beall, S. A., Boekelheide, K., & Johnson, K. J. (2005). Hybrid GPCR/cadherin (Celsr) pro-
teins in rat testis are expressed with cell type specificity and exhibit differential Sertoli
cell-germ cell adhesion activity.
Journal of Andrology
,
26
, 529-538.
Bellaiche, Y., Gho, M., Kaltschmidt, J. A., Brand, A. H., & Schweisguth, F. (2001). Frizzled
regulates localization of cell-fate determinants and mitotic spindle rotation during asym-
metric cell division.
Nature Cell Biology
,
3
, 50-57.
Berger-Muller, S., & Suzuki, T. (2011). Seven-pass transmembrane cadherins: Roles and
emerging mechanisms in axonal and dendritic patterning.
Molecular Neurobiology
,
44
,
313-320.
Bingham, S., Higashijima, S., Okamoto, H., & Chandrasekhar, A. (2002). The Zebrafish tri-
lobite gene is essential for tangential migration of branchiomotor neurons.
Developmental
Biology
,
242
, 149-160.
Carreira-Barbosa, F., Concha, M. L., Takeuchi, M., Ueno, N., Wilson, S. W., & Tada, M.
(2003). Prickle 1 regulates cell movements during gastrulation and neuronal migration in
zebrafish.
Development
,
130
, 4037-4046.
Carreira-Barbosa, F., Kajita, M., Morel, V., Wada, H., Okamoto, H., Martinez Arias, A.,
et al. (2009). Flamingo regulates epiboly and convergence/extension movements
through cell cohesive and signalling functions during zebrafish gastrulation.
Development
,
136
, 383-392.
Chae, J., Kim, M. J., Goo, J. H., Collier, S., Gubb, D., Charlton, J., et al. (1999). The Dro-
sophila tissue polarity gene starry night encodes a member of the protocadherin family.
Development
,
126
, 5421-5429.
Chandrasekhar, A. (2004). Turning heads: Development of vertebrate branchiomotor neu-
rons.
Developmental Dynamics
,
229
, 143-161.
Chen, W. S., Antic, D., Matis, M., Logan, C. Y., Povelones, M., Anderson, G. A., et al.
(2008). Asymmetric homotypic interactions of the atypical cadherin flamingo mediate
intercellular polarity signaling.
Cell
,
133
, 1093-1105.
Chen, P. L., & Clandinin, T. R. (2008). The cadherin Flamingo mediates level-dependent
interactions that guide photoreceptor target choice in Drosophila.
Neuron
,
58
, 26-33.
Curtin, J. A., Quint, E., Tsipouri, V., Arkell, R. M., Cattanach, B., Copp, A. J., et al. (2003).
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural
tube defects in the mouse.
Current Biology
,
13
, 1129-1133.
