Biomedical Engineering Reference
In-Depth Information
pathways imparting asymmetry throughout the entire cells makes them ide-
ally suitable for building the stunningly organized neuronal morphology that
is essential for neural circuit function. PCP and A-BP signaling, which
intimately interact with each other, are used for axon wiring, and they
can, in principle, also be used to regulate designs such as dendrites, axonal
and dendritic branches, and even spines (
Moreau et al., 2010
). These discov-
eries will not only provide insights of brain development but also identify the
components that may be affected in developmental disorders causing
nervous system disorders. When there is a need to steer growth cones to
repair brain circuits, the knowledge of how PCP signaling may guide
growth cones will be instrumental.
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