Biomedical Engineering Reference
In-Depth Information
A
Frizzled3
P
Frizzled3
B
Frizzled3
P
P
P
P
Disheveled
C
Vangl2
Frizzled3
P
Disheveled
Frizzled3
Figure 6.3 Regulation of Frizzled3 membrane localization by phosphorylation. (A) Friz-
zled3 exists mostly in intracellular vesicles. (B) Disheveled1 can cause Frizzled3 hyper-
phosphorylation and accumulation on plasma membrane, which stops PCP signaling.
(C) Vangl2 antagonizes Disheveled1-mediated Frizzled3 inactivation by promoting Friz-
zled3 endocyotosis. Vangl2 is enriched on tips of extending filopodia not in retracting
filopodia, suggesting Vangl2 activates PCP signaling in a subset of filopodia (
Shafer
et al., 2011
).
