Biomedical Engineering Reference
In-Depth Information
Figure 1.5 Less well-known PCP-related phenotypes. A and B show wild-type and fz
pupae, respectively. In a modest fraction of fz pupae, the wing everts forward instead of
posteriorly (as shown in B). Arrowheads point to the eye and arrows to the wing hinge re-
gion. C is awild-typewingandD is a distortedwing that results fromthe abnormal eversion
as shown inB. E
G arewings imaged by cuticle reflectionmicroscopy (E) andnormal bright
field microscopy (G) and a merged image (F). These panels were generously provided by
S. Collier. H is a wild-type wing and I the same region of a wing froma fly homozygous for a
mutation in Gliotactin. Note the lack of parallel alignment of neighboring hairs in (I).
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perhaps due to defects in cell rearrangements. This could be related to the
effects of the
fz
pathway on the movement of sheets of cells in vertebrates
(
Goodrich & Strutt, 2011
). Mutations in genes such as
fz
also inhibit the
repacking of pupal wing cells so that the fraction of hexagonal cells is de-
creased compared to wild type (
Classen, Anderson, Marois, & Eaton,
2005
). The connection between the altered hair polarity and the effect on
the repacking is unclear (
Classen et al., 2005; Ma et al., 2008
). An
