Biomedical Engineering Reference
In-Depth Information
A
Spinal cord
commissural
neurons
Frizzled3
Celsr3
Vangl2
Wild type
D
Wnts
A
“Open-
book”
A
V
P
P
FP
FP
D
V
B
Dopaminergic
Frizzled3
Celsr3
Vangl2
Serotonergic
Wnt5a
Serotonergic
C
D
Frizzled
Strabismus (Van Gogh)
Flamingo
Disheveled
Wnt5
Prickle
Flamingo
Disheveled
Dorsal
cluster
neurons
α
CB
α′
CA
β′
ISN
γ
PED
β
VNC
Figure 6.1 Evidence of PCP signaling in axon guidance. (A) Spinal cord commissural
axons reply on PCP signaling components for faithful anterior turning after crossing
the midline (
Lyuksyutova et al., 2003; Shafer, Onishi, Lo, Colakoglu, & Zou, 2011
). (B)
Dopaminergic and serotonergic axons in the midbrain and hindbrain are guided to
project along the anterior
-
posterior axis by PCP components (
Fenstermaker et al.,
2010
). (C) Drosophila mushroom body axon projection patterns are organized by PCP
components (
Shimizu, Sato, & Tabata, 2011
). (D) Drosophila sensory axons rely on core
PCP components for outgrowth (
Mrkusich, Flanagan, & Whitington, 2011
).
along the length of the spinal cord and detected by the receptor, Frizzled3, in
the commissural neurons (
Lyuksyutova et al., 2003
)(
Fig. 6.1A
). Studies in
Drosophila
showed that Derailed-expressing commissural axons only cross
the midline along the anterior commissure due to the repulsive function of
